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A Proposed Mechanism for Vitamin D Insufficiency and Schizophrenia Risk
Adjunctive Anti-Nausea Agent May Improve Fluvoxamine Treatment of OCD
First published in Psychiatry Weekly, Volume 9, Issue 9; June 23, 2014
Adjunctive use of the antiemitic agent ondansetron with fluvoxamine may improve OCD symptoms more effectively than fluvoxamine monotherapy, according to a study published in International Clinical Psychopharmacology. Forty-six patients with a Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score of ≥21 randomly received ondansetron 8 mg/day or placebo for 8 weeks. All participants received fluvoxamine 100 mg/day for the first 4 weeks of the study, followed by 200 mg/day for the remaining 4 weeks of the trial. Participants who received adjunctive ondansetron improved substantially on Y-BOCS obsession and compulsion subscale scores compared with placebo. Furthermore, adverse events differed little between the ondansetron and placebo groups. www.ncbi.nlm.nih.gov/pubmed/24850229
-LS